Association of tobacco smoke exposure with metabolic profile from childhood to early adulthood: the Special Turku Coronary Risk Factor Intervention Project
Authors' conclusion
Both passive and active tobacco smoke exposures during childhood and adolescence are detrimentally associated with circulating metabolic measures indicative of increased cardio-metabolic risk.
Study context
- Population
- Children followed to early adulthood in the STRIP cohort, metabolic measures at 9–19 yearsn = 539 at 9 years to 409 at 19 years
- Exposure
- Passive tobacco smoke exposure or daily smoking vs no exposure
- Outcome
- Comprehensive metabolic profile (NMR metabolomics)
- Follow-up
- 9, 11, 13, 15, 17 and 19 years
Methodological detailsrepeated measures, NMR metabolomics
- Repeated measures
- NMR metabolomics
Main finding
As reported in the abstract
β
0.34 SD
CI 0.17–0.51; P < 0.0001
ratio of monounsaturated fatty acids to total fatty acids
β
0.28 SD
CI 0.12–0.45; P = 0.001
VLDL particle size
β
−0.21 SD
CI −0.34 to −0.07; P = 0.003
HDL particle size
Observational data: associations, not effects.
Original publication
Association of tobacco smoke exposure with metabolic profile from childhood to early adulthood: the Special Turku Coronary Risk Factor Intervention Project. Eur J Prev Cardiol. Published 1 September 2023. doi:10.
Summarised from the published abstract; every number is checked against it