Prevention & lipidsCohort study
Association of tobacco smoke exposure with metabolic profile from childhood to early adulthood: the Special Turku Coronary Risk Factor Intervention Project
- Prospective cohort study
- repeated measures
- NMR metabolomics
Authors' conclusion
Both passive and active tobacco smoke exposures during childhood and adolescence are detrimentally associated with circulating metabolic measures indicative of increased cardio-metabolic risk.
Study context
- Population
- Children followed to early adulthood in the STRIP cohort, metabolic measures at 9–19 yearsn = 539 at 9 years to 409 at 19 years
- Exposure
- Passive tobacco smoke exposure or daily smoking vs no exposure
- Outcome
- Comprehensive metabolic profile (NMR metabolomics)
- Follow-up
- 9, 11, 13, 15, 17 and 19 years
Main finding
As reported in the abstract
- ratio of monounsaturated fatty acids to total fatty acids
- β 0.34 SD (CI 0.17–0.51); P < 0.0001
- VLDL particle size
- β 0.28 SD (CI 0.12–0.45); P = 0.001
- HDL particle size
- β −0.21 SD (CI −0.34 to −0.07); P = 0.003
Observational data: associations, not effects.
Original publication
Association of tobacco smoke exposure with metabolic profile from childhood to early adulthood: the Special Turku Coronary Risk Factor Intervention Project. Eur J Prev Cardiol. Published 1 September 2023. doi:10.1093/eurjpc/zwad285
Summarised from the published abstract; every number is checked against it