Heart failure & cardiomyopathiesCross-sectional study
Association of Ventricular–Arterial Coupling with Biomarkers Involved in Heart Failure Pathophysiology – The STANISLAS Cohort
- Cross-sectional analysis of a population-based family cohort (STANISLAS)
Authors' conclusion
Elevated MMP-2 and NT-proBNP levels correlate with better VAC (lower PWV/GLS), possibly indicating a compensatory cardiovascular response to regulate left ventricular pressure amidst cardiac remodelling and overload.
Study context
- Population
- Middle-aged individuals of parent and children generations, fourth visit of the STANISLAS family cohortmean age 48 ± 14 years
- Participants
- 1,309 individuals
- Outcome
- Association of 32 heart failure (HF)-related proteins with ventricular-arterial coupling (VAC) (PWV/GLS and Ea/Ees)
Main finding
As reported in the abstract
Association of HF-related proteins with VAC
- Positively associated with pulse wave velocity (PWV)/global longitudinal strain (GLS): FABP4, interleukin-6, GDF-15, MMP-1, MMP-9 and adrenomedullin
- Negatively associated with PWV/GLS: TGF beta receptor type 3, MMP-2 and NT-proBNP
- Multivariable models: only MMP-2 and NT-proBNP significantly and inversely associated with PWV/GLS, in the whole population and the parent generation
- Higher NT-proBNP negatively associated with elastance (Ea)/Ees in the whole cohort; not persisting in the parent subgroup
Observational data: associations, not effects.
Original publication
Association of Ventricular–Arterial Coupling with Biomarkers Involved in Heart Failure Pathophysiology – The STANISLAS Cohort. Eur J Heart Fail. Published 27 August 2024. doi:10.1002/ejhf.3411
Summarised from the published abstract; every number is checked against it