Association of weight change with cardiovascular events and all-cause mortality in obese participants with cardiovascular disease: a prospective cohort study
Authors' conclusion
Among obese individuals with CVD, large weight gain is associated with a higher risk of CV death and all-cause mortality. Further studies are needed to understand the exact mechanisms underlying the associations between weight loss or weight gain and mortality.
Study context
- Population
- Obese participants with established cardiovascular disease and repeated weight measurements, UK Biobankobese participants who had CV disease (CVD) with repeated weight measurements, 43.1% female, mean age 56.6 (SD: 7.2) years, median follow-up 13.9 (IQR: 13.1–14.6) years
- Participants
- 8,297 participants
- Exposure
- Weight change categories compared with stable weight
- Outcome
- CV death and all-cause mortality
- Follow-up
- Median 13.9 years
Main finding
As reported in the abstract
median follow-up 13.9 years
large weight gain vs stable weightHazard ratio (95% CI)
CV death; fully adjusted
3.05(1.40–6.67)
All-cause mortality; fully adjusted
1.93(1.15–3.26)
Observational data: associations, not effects.
Original publication
Association of weight change with cardiovascular events and all-cause mortality in obese participants with cardiovascular disease: a prospective cohort study. Heart. Published 16 January 2025. doi:10.
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