Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies
An erratum to this article was published (Circulation, 21 Mar 2017 ↗)
Authors' conclusion
Except for the association between cigarette smoking and provoked VTE, which is potentially mediated through comorbid conditions such as cancer, the modifiable traditional cardiovascular disease risk factors are not associated with increased VTE risk. Higher systolic blood pressure showed an inverse association with VTE.
Study context
- Population
- Participants of 9 prospective studies with measured baseline CVD risk factors and validated venous thromboembolism (VTE) events
- Participants
- 244,865 participants · 9 prospective studies
- Comparison
- Traditional CVD risk factors vs their absence
- Outcome
- Overall VTE
- Follow-up
- Mean 4.7 to 19.7 years per study
Methodological detailsrandom-effect
- Random-effect
Pooled result
As reported in the abstract
Hazard ratio (95% CI)
Hypertension
0.98(0.89–1.07)
Hyperlipidemia
0.97(0.88–1.08)
Diabetes mellitus
1.01(0.89–1.15)
Current smoking
1.19(1.08–1.32)
Further pooled results
| Outcome | HR (95% CI) | |
|---|---|---|
| VTE by SBP (continuous)SBP 160 mm Hg vs SBP 110 mm Hg · inverse association | 0.79 (0.68–0.92) | |
| 0.512Hazard ratio (log scale) |
Provoked and unprovoked VTE, current smoking (subtype)
| Comparison | HR (95% CI) | |
|---|---|---|
| Current smokingProvoked VTE, fully adjusted | 1.36 (1.22–1.52) | |
| Current smokingUnprovoked VTE, fully adjusted | 1.08 (0.90–1.29) | |
| 0.512Hazard ratio (log scale) |
VTE by SBP (continuous)
- No association of DBP or lipid measures with VTE
Original publication
Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies. Circulation. Published 9 November 2016. doi:10.
Summarised from the published abstract; every number is checked against it