Heart failure & cardiomyopathiesCohort study
Associations Between Baseline Heart Rate and Blood Pressure and Time to Events in Heart Failure with Reduced Ejection Fraction Patients: Data from the QUALIFY International Registry
- Registry-based cohort study
- international registry
Authors' conclusion
In patients with HFrEF and recent hospitalization, elevated RHR and lower SBP identify patients at increased risk for cardiovascular endpoints.
Study context
- Population
- HF and reduced ejection fraction (HFrEF) patients with a previous heart failure (HF) hospitalization within 1–15 months, QUALIFY registry, September 2013 to December 20145,138 with complete follow-up
- Participants
- 7,317 patients
- Exposure
- Baseline resting heart rate (RHR)/systolic blood pressure (SBP) phenotypes vs L-RHR/high SBP (H-SBP)
- Outcome
- CV death and HF hospitalization
Main finding
As reported in the abstract
Hazard ratio
1.83
95% CI 1.51–2.21
P < 0.001
H-RHR/L-SBP vs L-RHR/H-SBP
HR 1.83 (95% CI 1.51–2.21); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CV death | 2.70 (1.69–4.33) | P < 0.001 | |
| HF hospitalization | 1.62 (1.30–2.01) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Treatment with ACEi and beta-blockers (≥50% of target dose)
- Low-risk patients not well treated with ACEi (≤50% of target dose or no treatment)
- 48%
- Low-risk patients not well treated with beta-blockers (≤50% of target dose or no treatment)
- 46%
- L-RHR/H-SBP achieved ≥50% of target doses of ACEi and beta-blockers more frequently than the other groups
Original publication
Associations Between Baseline Heart Rate and Blood Pressure and Time to Events in Heart Failure with Reduced Ejection Fraction Patients: Data from the QUALIFY International Registry. Eur J Heart Fail. Published 18 September 2023. doi:10.1002/ejhf.3023
Summarised from the published abstract; every number is checked against it