Arrhythmias & electrophysiology
Associations Between Objective Sleep Characteristics From Wearable Physiologic Monitors and Incident Atrial Fibrillation
Authors' conclusion
Wearable-derived sleep parameters are independently associated with AF risk. Prolonged total and nonmain sleep, reduced deep and REM sleep, and increased light sleep are independently associated with incident AF, supporting their potential role in AF risk stratification and prevention.
Study context
- Population
- Participants in the All of Us Research Program with wearable-derived sleep data and no baseline atrial fibrillation (AF)participants followed for a median of 935 days, incident AF n = 437 (0.84%)
- Participants
- 52,952 participants
- Exposure
- Associations between objectively measured sleep parameters, including total sleep duration and sleep stages and incident AF
- Outcome
- Incident AF by demographic and clinical characteristics
Main finding
As reported in the abstract
- Incident AF was associated with older age, male sex, White race, smoking, and comorbidities
- all P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident AF by total sleep duration>9 hoursvs 6-9hLonger total sleep duration linked to increased AF risk | 1.47 (1.12–1.94) | |
| Incident AF by nonmain sleep durationNonmain sleep ≥2 hoursvs 1-2 hoursIncreased risk | 1.65 (1.23–2.20) | |
| 0.512Hazard ratio (log scale) |
- Incident AF by total sleep duration: adjusted for demographic, behavioral, and clinical covariates
Incident AF by sleep stages
- Duration of deep and rapid eye movement sleep was inversely associated with AF, whereas light sleep was associated with increased risk
Original publication
Associations Between Objective Sleep Characteristics From Wearable Physiologic Monitors and Incident Atrial Fibrillation. JACC Adv. Published 21 January 2026. doi:10.
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