Acute cardiac care & resuscitationCohort study
Associations between pulsed oxygen saturation during out-of-hospital cardiopulmonary resuscitation, cardiopulmonary resuscitation quality and return of spontaneous circulation
- Observational analysis of out-of-hospital cardiac arrest events
Authors' conclusion
Higher event-average SpO2 was associated with higher probability of unadjusted and adjusted sustained ROSC but not with neurological intact survival. Cycle-average SpO2 was not associated with chest compressions quality metrics.
Study context
- Population
- Index out-of-hospital cardiac arrest (OHCA) events with recorded pulsed oxygen saturation (SpO2) during resuscitationindex OHCA
- Participants
- 98 participants
- Exposure
- Event-average SpO2 and sustained return-of-spontaneous-circulation (ROSC)
Main finding
As reported in the abstract
Event-average SpO2
Median event-average SpO2 ([Q1, Q3])
55.0 (38.8, 72.3)
Observational data: associations, not effects.
Further findings
Sustained ROSC
| Comparison | adjusted odds ratio (95% CI) | P value | |
|---|---|---|---|
| SpO2 · after adjusting for confounders | 1.05 (1.02–1.08) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
Survival to hospital admission
| Comparison | adjusted odds ratio (95% CI) | P value | |
|---|---|---|---|
| Event-average SpO2 | 1.03 (1.01–1.05) | P = 0.005 | |
| 0.512Adjusted odds ratio (log scale) |
Neurological intact survival
| Comparison | adjusted odds ratio (95% CI) | P value | |
|---|---|---|---|
| Event-average SpO2 | 1.00 (0.96–1.05) | P = 0.79 | |
| 0.512Adjusted odds ratio (log scale) |
Median
| Outcome | Sustained ROSC | No sustained ROSC | Estimate | P value |
|---|---|---|---|---|
| Event-level average SpO2 by sustained ROSC · higher SpO2 with sustained ROSC | 72.3 (IQR 57.0–82.9) | 48.0 (IQR 34.9–65.4) | P < 0.001 |
SpO2 as a predictor of sustained ROSC (ROC analysis)
- Area under the curve
- 0.77 [95% CI, 0.68-0.86]
- Optimal cut point
- 71.0
- Sensitivity
- 58
- Specificity
- 0.85
Chest compressions metrics
- Higher cycle-average SpO2 was not associated with better chest compressions metrics
Original publication
Associations between pulsed oxygen saturation during out-of-hospital cardiopulmonary resuscitation, cardiopulmonary resuscitation quality and return of spontaneous circulation. Resuscitation. Published 23 July 2026. doi:10.1016/j.resuscitation.2026.111215
Summarised from the published abstract; every number is checked against it