Valvular & structural heart diseaseCohort study
Associations between sweetened beverage consumption, degenerative valvular heart disease, and related events: a prospective study from UK Biobank
- Prospective cohort study
Authors' conclusion
Lower consumption of SSBs or ASBs may reduce the risk of degenerative VHD and VHD-related events.
Study context
- Population
- UK Biobank participants who completed at least one dietary questionnaire
- Participants
- 167,801 participants
- Exposure
- Sweetened beverage consumption vs non-consumption
- Outcome
- Degenerative VHD: AS, aortic valve regurgitation (AR) and mitral valve regurgitation (MR) events
- Follow-up
- Median 14.53 years
Main finding
As reported in the abstract
AS, AR and MR events
Each group vs non-consumersHazard ratio (95% CI)
ASBs >1 drink/dayAS
1.36(1.10–1.68)
ASBs >1 drink/dayAR
1.42(1.02–2.00)
ASBs >1 drink/dayMR
1.35(1.10–1.64)
SSBs >1 drinkMR
1.47(1.22–1.77)
- AS events
- 1464
- AR events
- 584
- MR events
- 1744
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Substitution of SSBs or ASBs per day with NJs — NJs vs SSBs · MR events | 0.83 (0.72–0.94) | |
| Substitution of SSBs or ASBs per day with NJs — NJs vs ASBs · AS events | 0.81 (0.69–0.94) | |
| 0.512Hazard ratio (log scale) |
Valvular heart disease (VHD)-related interventions, deaths or CV events
- Results largely consistent
Original publication
Associations between sweetened beverage consumption, degenerative valvular heart disease, and related events: a prospective study from UK Biobank. Eur J Prev Cardiol. Published 13 May 2025. doi:10.1093/eurjpc/zwaf293
Summarised from the published abstract; every number is checked against it