Arrhythmias & electrophysiology
Associations of accelerometer-derived moderate-to-vigorous physical activity and atrioventricular block in a healthy elderly population
Main finding · Second- or third-degree AV blockResult — go to the resultHazard ratio 0.37 95% CI 0.19–0.73Authors' conclusion
In the healthy elderly population, MVPA was associated with a lower risk of second- or third-degree AV block, which correlates with the reduction of normalized PQ interval. However, excessive MVPA attenuated the results.
Study context
- Population
- UK Biobank participants ≥60 years of age with no history of hypertension, diabetes mellitus, dyslipidemia, and coronary heart diseaseparticipants analyzed
- Participants
- 23,590 participants
- Comparison
- Associations of accelerometer-derived moderate-to-vigorous physical activity (MVPA) with atrioventricular (AV) block, by MVPA quintile
- Outcome
- Second- or third-degree AV block
- Follow-up
- Median 6.1 years
Methodological detailsUK Biobank, Cox regression analysis, linear regression analysis
- UK Biobank
- Cox regression analysis
- Linear regression analysis
Main finding
As reported in the abstract
Hazard ratio
0.37
95% CI 0.19–0.73
P = 0.004
Quintile 4vs quintile 1
HR 0.37 (95% CI 0.19–0.73); P = 0.004
- Primary outcome events
- 115
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Third-degree AV blockQuintile 4vs quintile 1 | 0.29 (0.11–0.74) | P = 0.010 | |
| 0.10.31310Hazard ratio (log scale) |
Pacemaker implantation
- Same pattern consistently observed
Normalized PQ interval (msec), per 150 minutes per week increase in MVPA
- β
- −2.13
- 95% CI
- 0-3.03 to −1.24
- P
- P < 0.001
- Independently negatively associated
Baseline characteristics
- Mean age
- 63.8 ± 2.8 years
- Women
- 57.4%
Original publication
Associations of accelerometer-derived moderate-to-vigorous physical activity and atrioventricular block in a healthy elderly population. Heart Rhythm. Published 9 January 2025. doi:10.
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