Coronary disease & ACSMeta-analysis
Associations of Central Adiposity With Subclinical Coronary Calcification and Disease Progression
- systematic review and meta-analysis
- random-effects models
- meta-regression
Authors' conclusion
Central adiposity measures (WHR and WC) show stronger associations with CAC presence and progression than BMI, supporting their use as markers of cardiovascular risk while highlighting limitations of BMI alone. (Anthropometrics and subclinical coronary artery calcification: a systematic review and meta-analysis; CRD420251083057).
Study context
- Population
- Individuals without established cardiovascular diseaseForty-nine studies (33 coronary artery calcium (CAC) presence, 16 progression) across 10 countries · CAC presence 43,490 · CAC progression 25,141
- Comparison
- associations of body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) with CAC presence and progression
Pooled result
As reported in the abstract
WHR SMD (higher in those with CAC >0), 95% CI 0.35-0.56, I2 = 81%
0.46
WC SMD (higher in those with CAC >0), 95% CI 0.23-0.40, I2 = 86%
0.32
BMI SMD (not significant), 95% CI −0.03-0.29, I2 = 98%
0.13
WHR showed a stronger association than WC
P = 0.04
Further pooled results
CAC progression · mean follow-up 4.9 ± 3.0 years
- WC SMD, 95% CI 0.27-0.42, I2 = 64%
- 0.34
- BMI SMD, 95% CI 0.16-0.27, I2 = 29%
- 0.21
- WC more strongly associated than BMI
- P = 0.01
Meta-regression, CAC presence
- attenuation with higher hypertension prevalence
Original publication
Summarised from the published abstract; every number is checked against it