Prevention & lipidsCohort study
Associations of Circulating ANGPTL3, C-Terminal Domain–Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality
- Prospective cohort study with mechanistic in vitro study
- two cohorts (LURIC, getABI)
- recombinant protein assays
Authors' conclusion
However, ANGPTL3/8, LDL-C, and triglyceride levels were not associated with cardiovascular death in the LURIC and getABI cohorts. In contrast, concentrations of ANGPTL4/8 and particularly CD-ANGPTL4 were positively associated with inflammation, the prevalence of diabetes, and cardiovascular mortality.
Study context
- Population
- LURIC participants undergoing coronary angiography and getABI participants undergoing ankle brachial index measurementLURIC 2394
- Exposure
- Third vs first tertile of circulating ANGPTL proteins and complexes
- Outcome
- CV death
- Follow-up
- Median 9.80 (IQR 8.75-10.40) years in LURIC; 7.06 (7.00-7.14) years in getABI
Main finding
As reported in the abstract
CV mortality, third vs first tertile (adjusted for sex, age, BMI, DM)
Third tertile vs First tertileHazard ratio (CI)
ANGPTL4/8, LURIC
1.47(1.15–1.88)
ANGPTL4/8, getABI
1.68(1.25–2.27)
CD-ANGPTL4, LURIC
2.44(1.86–3.20)
CD-ANGPTL4, getABI
2.76(2.00–3.82)
Observational data: associations, not effects.
Further findings
ANGPTL3/8 effect on GPIHBP1-LPL activity and lipids
- ANGPTL3/8 positively associated with LDL-C and TG
- P < 0.001
- ANGPTL3/8 potently inhibited GPIHBP1-LPL activity
DM prevalence and CRP
- ANGPTL4/8 and especially CD-ANGPTL4 positively associated with DM prevalence and CRP
- P < 0.001
Original publication
Associations of Circulating ANGPTL3, C-Terminal Domain–Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality. Circulation. Published 11 October 2024. doi:10.1161/circulationaha.124.069272
Summarised from the published abstract; every number is checked against it