Associations of N-terminal pro-B-type natriuretic peptide, estimated glomerular filtration rate, and mortality in US adults
Authors' conclusion
Despite its strong inverse association with eGFR, NT-proBNP has robust associations with mortality across the full range of kidney function in the general US adult population.
Study context
- Population
- US adults without prior CVD (National Health and Nutrition Examination Survey (NHANES) 1999 to 2004)mean age 43 years
- Participants
- 11,456 adults
- Exposure
- NT-proBNP levels across estimated glomerular filtration rate (eGFR) categories
- Outcome
- All-cause and CV mortality by NT-proBNP across eGFR categories
- Follow-up
- Median 17.6 years
Methodological detailscross-sectional and prospective analyses, NHANES 1999 to 2004
- Cross-sectional and prospective analyses
- NHANES 1999 to 2004
Main finding
As reported in the abstract
Mortality per doubling of NT-proBNP
NT-proBNP per doublingHazard ratio (95% CI)
All-cause mortality
1.20(1.16–1.25)
CV mortality
1.34(1.25–1.44)
Per doubling, as printed
- Deaths
- 2,275 (622 cardiovascular)
- Associations similar across eGFR categories
- P for interaction > 0.10
Observational data: associations, not effects.
Further findings
Cross-sectional NT-proBNP per 15-unit decrease in eGFR
- eGFR<30
- 4.3-fold higher
- eGFR 30 to 60
- 1.7-fold higher
- eGFR 61 to 90
- 1.4-fold higher
- eGFR 91 to 120 mL/min/1.73 m²
- 1.1-fold higher
NT-proBNP≥450 pg/mL and eGFR<60 vs NT-proBNP<125 pg/mL and eGFR>90 mL/min/1.73m2
- All-cause mortality
- 3.4-fold higher
- CV mortality
- 5.5-fold higher
Original publication
Associations of N-terminal pro-B-type natriuretic peptide, estimated glomerular filtration rate, and mortality in US adults. Am Heart J. Published 7 June 2023. doi:10.
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