Pulmonary vascular disease & thromboembolism
Associations of PM2.5 components, residential greenness, and heatwaves with incident venous thromboembolism
Authors' conclusion
This study identified that exposure to specific PM2.5 components, low residential greenness, and heatwaves were associated with elevated VTE risk.
Study context
- Population
- UK Biobank participants (mean age 56.5 years; 54.3% female)9,988 incident venous thromboembolism (VTE) cases
- Participants
- 483,610 participants
- Exposure
- Higher vs lower exposure to PM2.5 components, residential greenness and heatwaves
- Outcome
- Incident VTE (hospital admission and death records)
- Follow-up
- Median 11.83 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Incident VTE
Hazard ratio (95% CI)
Elemental carbon
1.052(1.005–1.101)
Sulfate
1.064(1.001–1.130)
Ammonium
1.090(1.010–1.176)
Residential greenness
0.944(0.916–0.972)
Per IQR increase, as printed
- Heatwaves, HR for incident VTE across heatwave definitions
- 1.149 (1.137, 1.161) to 1.407 (1.396, 1.417)
Observational data: associations, not effects.
Further findings
Interactions on VTE risk
- Significant additive interactions with heatwaves for sulfate and ammonium, not consistently for other components or greenness
- Polygenic risk score: significant additive interactions with ammonium and nitrate, multiplicative interaction with residential greenness
Original publication
Associations of PM2.5 components, residential greenness, and heatwaves with incident venous thromboembolism. Eur J Prev Cardiol. Published 4 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →