Coronary disease & ACSCross-sectional study
Associations of Self-Reported Race, Social Determinants of Health, and Polygenic Risk With Coronary Heart Disease
- Cross-sectional study
Authors' conclusion
Increased odds of CHD in people who self-report as Black are likely due to a higher SDOH burden. SDOH and PRS were independently associated with CHD.
Study context
- Population
- All of Us participants with social determinants of health (SDOH) and whole-genome sequencing data, UStest set n = 33,628
- Participants
- 67,256 participants
- Exposure
- SDOH score and polygenic risk score (PRS) for coronary heart disease (CHD)
- Outcome
- CHD
Main finding
As reported in the abstract
CHD per 1-SD increase, adjusted for clinical risk factors (test set)
Odds ratio (95% CI)
SDOHCHD (per 1-SD)
1.32(1.23–1.41)
PRSCHD (per 1-SD)
1.36(1.28–1.44)
Per 1-SD, as printed
Observational data: associations, not effects.
Further findings
Self-reported race and CHD
- SDOHCHD highest in self-reported Black and Hispanic people
- Black people had higher odds of CHD than White people, but not after adjustment for SDOHCHD
SDOH domains and CHD
- SDOH across 5 domains (food insecurity, income, education, health literacy, neighbourhood disorder, loneliness) associated with CHD
- SDOHCHD and PRS for CHD (PRSCHD) weakly correlated
Incident CHD events (n = 52) · median follow-up 214 days (Q1-Q3: 88 days)
- SDOHCHD and PRSCHD associated with incident CHD
Original publication
Associations of Self-Reported Race, Social Determinants of Health, and Polygenic Risk With Coronary Heart Disease. J Am Coll Cardiol. Published 26 November 2024. doi:10.1016/j.jacc.2024.06.052
Summarised from the published abstract; every number is checked against it