Cardiometabolic & kidneyCohort study
Associations of uric acid with the risk of cardiovascular disease and all-cause mortality among individuals with chronic kidney disease: the Kailuan Study
- Prospective cohort study
Authors' conclusion
In individuals with CKD, a higher concentration of UA was associated with a higher risk of myocardial infarction, heart failure, and all-cause mortality, following a dose-response relationship.
Study context
- Population
- Individuals with chronic kidney disease (CKD) free of cardiovascular disease (CVD) at recruitment, Kailuan Study
- Participants
- 27,707 individuals
- Exposure
- Highest vs lowest uric acid (UA) tertile
- Outcome
- MI, HF, stroke and all-cause mortality
- Follow-up
- Median 11-12 years
Main finding
As reported in the abstract
Highest UA tertile vs Lowest UA tertileHazard ratio (95% CI)
MI
1.38(1.13–1.67)
HF
1.60(1.38–1.85)
stroke
1.01(0.91–1.12)
all-cause mortality
1.29(1.21–1.38)
- MI events
- 674
- HF events
- 1197
- Strokes
- 2406
- Total deaths
- 5676
Observational data: associations, not effects.
Further findings
HF and all-cause mortality, by eGFR (subgroup)
- Associations stronger with eGFR <45 mL/min/1.73 m²
- P for interaction < 0.05
All-cause mortality, by DM (subgroup)
- Association stronger without DM than with DM
- P for interaction < 0.05
Original publication
Associations of uric acid with the risk of cardiovascular disease and all-cause mortality among individuals with chronic kidney disease: the Kailuan Study. Eur J Prev Cardiol. Published 1 July 2024. doi:10.1093/eurjpc/zwae222
Summarised from the published abstract; every number is checked against it