Prevention & lipidsCross-sectional study
Associations of visit-to-visit lipid variability with coronary artery calcification and cardiovascular event in statin-naïve Koreans
- Cross-sectional analysis and cohort study
Authors' conclusion
These findings suggest that visit-to-visit lipid variability is independently associated with subclinical coronary atherosclerosis and cardiovascular risk in statin-naïve individuals.
Study context
- Population
- Statin-naïve Korean individuals59,879 cross-sectional
- Exposure
- Highest vs lowest quartile of visit-to-visit lipid variability
- Outcome
- CAC score and CV events (self-reported CAD and stroke)
- Follow-up
- Median 2.8 years (CV events)
Main finding
CAC score, LDL-C variability (VIM)
Fold increase in coronary artery calcification (CAC) score
1.42
95% CI 1.22–1.65
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CV events, LDL-C variability (VIM) · median follow-up 2.8 years · highest VIM variability | 1.41 (1.13–1.75) | |
| 0.512Hazard ratio (log scale) |
- CV events, low-density lipoprotein cholesterol (LDL-C) variability (VIM) — CV events identified
- 664
CV events, LDL-C variability (VIM) · median follow-up 2.8 years
- Only LDL-C variability associated with increased CV event risk
Original publication
Associations of visit-to-visit lipid variability with coronary artery calcification and cardiovascular event in statin-naïve Koreans. Eur J Prev Cardiol. Published 12 May 2025. doi:10.1093/eurjpc/zwaf191
Summarised from the published abstract; every number is checked against it