Coronary disease & ACSMechanistic study
Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification
- Mechanistic study
- bioinformatic deconvolution of bulk plaque microarrays
- QTL analyses
- in vitro silencing
Authors' conclusion
The study revealed novel CAD-associated variants that may be functionally linked to SMCs in atherosclerotic plaques.
Study context
- Population
- Patients undergoing carotid endarterectomy (Biobank of Karolinska Endarterectomies (BiKE) biobank)
- Participants
- 125 BiKE carotid plaques
Main finding
As reported in the abstract
Plaque cell fractions (deconvoluted from Single cell RNA sequencing (scRNAseq)) by symptom status, patient clusters, cfQTLs and ARNTL silencing in SMCs
Clustering by plaque cell fractions revealed three patient groups with differences in stability profiles and associations to stroke, even during long-term follow-up
3
Original publication
Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification. Eur Heart J. Published 18 November 2024. doi:10.1093/eurheartj/ehae768
Summarised from the published abstract; every number is checked against it