Atherosclerotic Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations
Authors' conclusion
This cross-sectional study found that use of the PREVENT equations was associated with fewer US adults being eligible for primary prevention statin therapy; however, the majority of adults eligible for receiving such therapy based on PREVENT equations did not report statin use.
Study context
- Population
- US adults aged 40 to 75 years without known atherosclerotic cardiovascular disease (ASCVD), NHANES 2017 to March 2020weighted sample
- Participants
- 3,785 adults
- Exposure
- PREVENT equations vs pooled cohort equations (PCEs)
- Outcome
- 10-year ASCVD risk and eligibility for primary prevention statin therapy
Methodological detailsnationally representative weighted sample
- Nationally representative weighted sample
Main finding
As reported in the abstract
Mean estimated 10-year ASCVD risk; statin eligibility
| Group | Value | Adults meeting criteria for primary prevention statins |
|---|---|---|
| PCEs | mean 8.0% (95% CI 7.6%–8.4%) | 45.4 million (95% CI, 40.3 million-50.4 million) |
| PREVENT | mean 4.3% (95% CI 4.1%–4.5%) | 28.3 million (95% CI, 25.2 million-31.4 million) |
Value
PCEsmean 8.0% (95% CI 7.6%–8.4%)
PREVENTmean 4.3% (95% CI 4.1%–4.5%)
Adults meeting criteria for primary prevention statins
PCEs45.4 million (95% CI, 40.3 million-50.4 million)
PREVENT28.3 million (95% CI, 25.2 million-31.4 million)
- Adults recommended statins by PCEs no longer recommended by PREVENT
- 17.3 million (95% CI, 14.8 million-19.7 million)
- Of these, currently taking statins
- 4.1 million (95% CI, 2.8 million-5.5 million)
Observational data: associations, not effects.
Further findings
Mean
| Outcome | PREVENT | PCEs |
|---|---|---|
| Mean 10-year ASCVD risk, Black adults (subgroup)Lower with PREVENT across all age, sex and racial subgroups | 5.1% (95% CI 4.7%–5.4%) | 10.9% (95% CI 10.1%–11.7%) |
| Mean 10-year ASCVD risk, aged 70 to 75 years (subgroup) | 10.2% (95% CI 9.6%–10.8%) | 22.8% (95% CI 21.6%–24.1%) |
Current statin use among adults eligible by PREVENT
- Reported currently taking statins
- 44.1% (95% CI, 38.6%-49.5%)
- Eligible but not taking statins
- 15.8 million (95% CI, 13.4 million-18.2 million)
Original publication
Atherosclerotic Cardiovascular Disease Risk Estimates Using the Predicting Risk of Cardiovascular Disease Events Equations. JAMA Intern Med. Published 1 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →