Cardio-oncology & otherCohort study
Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer
- Prospective cohort study
- time-dependent covariate
- 1-year blanking period
Authors' conclusion
Atherosclerotic cardiovascular disease is associated with a significantly increased risk of cancer, specifically metastasis at the time of cancer diagnosis, particularly in middle-aged adults.
Study context
- Population
- Self-referred adults free of cancer and atherosclerotic CVD at enrollment in a preventive health care program
- Participants
- 21,654 adults
- Exposure
- Incident atherosclerotic CVD vs no atherosclerotic CVD
- atherosclerotic cardiovascular diseasen = 1,333
- Outcome
- Metastatic cancer at the time of cancer diagnosis
- Follow-up
- Median 6 years (Q1-Q3: 3-12 years)
Main finding
Cancer metastasis at diagnosis · median follow-up 6 years
Hazard ratio
1.75
95% CI 1.33–2.29
Atherosclerotic CVD vs No atherosclerotic CVD
HR 1.75 (95% CI 1.33–2.29)
As reported in the abstract
- Incident atherosclerotic CVD cases
- 1,333 (6.2%)
- Incident cancer cases
- 1,793 (8.3%)
- Nonmetastatic at diagnosis
- 1,036 (4.8 %)
- Metastatic at diagnosis
- 757 (3.5%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Cancer metastasis at diagnosis, by age (subgroup) — Atherosclerotic CVD vs No atherosclerotic CVD · middle-aged adults (≤54 years) | 1.64 (1.03–2.61) | P = 0.036 | |
| Cancer metastasis at diagnosis, by age (subgroup) — Atherosclerotic CVD vs No atherosclerotic CVD · older adults (>54 years) | 1.11 (0.78–1.60) | P = 0.56 | |
| 0.20.5125Hazard ratio (log scale) |
- Cancer metastasis at diagnosis, by age (subgroup): interaction P = 0.039
Original publication
Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer. JACC CardioOncol. Published 1 October 2024. doi:10.1016/j.jaccao.2024.07.020
Summarised from the published abstract; every number is checked against it