Valvular & structural heart diseaseCohort study
Atrial Fibrillation and Tricuspid Regurgitation in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair
- Cohort study
Authors' conclusion
Patients with AF, compared with those without AF, experienced greater incidence and progression and less common improvement of TR after M-TEER. In addition, both AF and TR appeared to be independently associated with worse right ventricular status and an increased risk for HF outcomes.
Study context
- Population
- Patients undergoing mitral valve transcatheter edge-to-edge repair (M-TEER)
- Participants
- 1,184 / 229 / 1,423 / 830
- Exposure
- Atrial fibrillation (AF) and/or significant tricuspid regurgitation (TR) vs no AF and no TR after M-TEER
- No AF and no TRn = 1,184reference
- No AF with significant TRn = 229
- AF and no TRn = 1,423
- AF with significant TRn = 830
- Outcome
- CV death or HF hospitalization
Main finding
As reported in the abstract
TR moderate or greater after M-TEER associated with higher adjusted risk of CV death or heart failure (HF) hospitalization, especially with AF
Pinteraction = 0.02
Observational data: associations, not effects.
Further findings
TR prevalence and course by AF
- AF associated with higher prevalence of significant TR at baseline, more frequent TR progression and less common improvement during follow-up
Right ventricular remodeling and dysfunction
- Both AF and TR appeared independently associated with RV remodeling and dysfunction, with distinct patterns by MR and TR pathologies
Original publication
Atrial Fibrillation and Tricuspid Regurgitation in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair. JACC Cardiovasc Interv. Published 9 January 2026. doi:10.1016/j.jcin.2025.10.041
Summarised from the published abstract; every number is checked against it