Arrhythmias & electrophysiologyResearch article
Atrial Fibrillation Burden and Clinical Outcomes After Catheter Ablation vs Lifestyle Modification With Antiarrhythmic Drugs
- per-protocol analysis
Authors' conclusion
In this per-protocol analysis, CA resulted in superior rhythm control compared with LFM + AAD therapy. AF burden reduction was accompanied by fewer AF-related hospitalizations or emergency visits. (PRAGUE-25 Trial: Catheter Ablation vs. AADs and Risk Factor Modification; NCT04011800).
Study context
- Population
- Obese patients with atrial fibrillation (AF)randomized, 96 catheter ablation (CA) and 83 LFM + AAD patients included in the per-protocol analysis · CA 96 · LFM + AAD 83
- Participants
- 203 patients
- Comparison
- CA vs LFM + AAD per-protocol populations
- CAn = 96
- LFM + AADn = 83
Main finding
As reported in the abstract
P = 0.39
Further findings
AF-related hospitalizations or emergency visits · during the study course
P = 0.026
Major adverse cardiovascular events (composite of stroke, cardiovascular death, or heart failure hospitalization) · during the study course · rare and similar between groups
P = 0.99
| Outcome | P value |
|---|---|
| AF burden · 6, 9, and 12 months · lower in the CA group | all P < 0.001 |
Baseline characteristics
- Mean age
- 60 ± 9 years
- Men
- 68.5%
- Mean body mass index
- 35 ± 3 kg/m²
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Summarised from the published abstract; every number is checked against it