Arrhythmias & electrophysiology
Atrial Fibrillation Burden on a 14-Day ECG Monitor: Findings From the GUARD-AF Trial Screening Arm
Authors' conclusion
Most AF detected in these older patients was very low burden. However, one-quarter of those with AF had multiple hours of AF, raising concern about stroke risk.
Study context
- Population
- Adults ≥70 years without prior atrial fibrillation (AF) diagnosis screened with a 14-day continuous ECG patch monitor (2019–2021)analyzable patches (95%)
- Participants
- 5,684 adults
- Outcome
- Frequency of AF and distribution of AF burden
- Follow-up
- 14-day monitoring
Methodological detailsscreening arm of a randomized AF screening trial
- Screening arm of a randomized AF screening trial
Main finding
As reported in the abstract
AF detection and AF burden
- AF detected
- 252 (4.4%)
- Continuous AF
- 29 (0.5%)
- Paroxysmal AF
- 223 (3.9%)
- Median percent time in AF (paroxysmal AF), Q1-Q3 0.02%-2.48%
- 0.46%
- Median time in AF (paroxysmal AF), Q1-Q3 3-454 minutes
- 75 minutes
- Median longest episode (paroxysmal AF), Q1-Q3 2-245 minutes
- 38 minutes
- Upper quartile threshold of 2.48% time in AF corresponded to
- 7.6 hours
Observational data: associations, not effects.
Further findings
Factors associated with screen-detected AF (multivariable model)
| OR (95% CI) | ||
|---|---|---|
| Age >80 years | 1.46 (1.06–2.02) | |
| 0.512Odds ratio (log scale) |
Original publication
Atrial Fibrillation Burden on a 14-Day ECG Monitor: Findings From the GUARD-AF Trial Screening Arm. JACC Clin Electrophysiol. Published 1 September 2024. doi:10.
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