Arrhythmias & electrophysiology
Atrial fibrillation in embolic stroke of undetermined source: role of advanced imaging of left atrial function
Authors' conclusion
The novel PADS score can identify the risk of AF on prolonged monitoring with ILR following ESUS and should be considered a dedicated risk stratification tool for decision-making regarding the screening strategy for AF in stroke.
Study context
- Population
- Patients with embolic stroke of undetermined source (ESUS) referred for implantable loop recorder (ILR) implantation, December 2009 to September 2019293 stroke, 30 TIA
- Participants
- 323 patients
- Outcome
- AF detection on ILR monitoring; risk prediction model for AF (PADS score)
- Follow-up
- Mean 710 days
Methodological detailssingle-centre, risk prediction model, internal validation by bootstrapping
- Single-centre
- Risk prediction model
- Internal validation by bootstrapping
Main finding
As reported in the abstract
PADS score for AF identification
- Atrial fibrillation (AF) of any duration detected
- 47.1%
- Lateral PA (increasing), OR
- 1.011
- Age (increasing), OR
- 1.035
- Diastolic BP (higher), OR
- 1.027
- Left atrial (LA) reservoir strain (abnormal), OR
- 0.973
- Model discrimination, AUC
- 0.72
- Bootstrap internal validation (1000 samples of 150 patients), AUC
- 0.73
Observational data: associations, not effects.
Original publication
Atrial fibrillation in embolic stroke of undetermined source: role of advanced imaging of left atrial function. Eur J Prev Cardiol. Published 11 July 2023. doi:10.
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