Heart failure & cardiomyopathiesCohort study
Atrial Fibrillation in Genotyped Dilated Cardiomyopathy: Epidemiology, Risk Factors, and Outcomes: Insights From the SHaRe Registry
- observational cohort study
Authors' conclusion
In this large genotyped DCM cohort, AF burden and incident AF risk varied across genotypes. Only LMNA was associated with an increased risk of incident AF. AF onset was independently associated with adverse outcomes, supporting genotype-guided AF surveillance and management in DCM.
Study context
- Population
- Genotyped patients with dilated cardiomyopathy (DCM) from the SHaRe (Sarcomeric Human Cardiomyopathy Registry)genotyped patients with DCM, 35% were G[+]
- Participants
- 3,117 patients
- Exposure
- Atrial fibrillation (AF) prevalence, incidence, and clinical characteristics by genotype; AF as a time-dependent variable for clinical outcomes
Main finding
As reported in the abstract
Prevalent AF
12.3% (n=384)
Observational data: associations, not effects.
Further findings
| Outcome | Values | hazard ratio (95% CI) | P value | |
|---|---|---|---|---|
| AF incidence and cumulative AF prevalence by genotype; incident AF · incident AF; only genotype independently associated | LMNA AF incidence 7.6/100 patient-years · Cumulative AF prevalence 56.7% · TTN AF incidence 2.1 per 100 patient-years · Cumulative AF prevalence 24.4% | 5.52 (3.84–7.95) | P < 0.001 | |
| Composite clinical outcome (heart failure, ventricular arrhythmias, and all-cause mortality) · higher risk with AF; AF as time-dependent variable | 1.58 (1.29–1.94) | P < 0.001 | ||
| 0.10.31310Hazard ratio (log scale) |
Incident AF among patients without prevalent AF and with follow-up · median of 4.5 years (interquartile range, 1.6-9.0)
- Of 2491 patients without prevalent AF and with follow-up, developed AF
- 312 (12.5%)
Cumulative AF prevalence among 2851 patients with follow-up
- Cumulative AF prevalence
- 23.6%
AF incidence and cumulative AF prevalence by genotype; incident AF
- TTN comparable to G(-) patients
Other factors associated with incident AF
- Older age, male sex, and prior heart failure hospitalization independently associated with incident AF
Original publication
Summarised from the published abstract; every number is checked against it