Arrhythmias & electrophysiologyRandomised controlled trial
Atrial fibrillation progression after cryoablation vs. radiofrequency ablation: the CIRCA-DOSE trial
- Randomised controlled trial
Authors' conclusion
Catheter ablation of paroxysmal AF using radiofrequency energy was associated with fewer patients developing persistent AF on follow-up.
Study context
- Population
- Patients with drug-refractory paroxysmal atrial fibrillation (AF)
- Participants
- 346 patients
- Comparison
- Contact-force-guided RF ablation vs 4 min vs 2 min cryoballoon ablation
- CF-RFn = 115reference
- CRYO-4n = 115
- CRYO-2n = 116
- Primary endpoint
- First episode of persistent atrial tachyarrhythmia (implantable cardiac monitor follow-up)
- Follow-up
- Median 944.0 days (IQR 612.5-1104)
Primary result
As reported in the abstract
Persistent atrial tachyarrhythmia · median 944.0 days
- Difference across the three groups
- P = 0.03
Secondary outcomes
Recurrence of any atrial tachyarrhythmia ≥30 s
| Outcome | CF-RF | CRYO-4 | CRYO-2 |
|---|---|---|---|
| Reduction in AF burden vs pre-ablation monitoring | median 99.5% (IQR 94.0%–100.0%) | median 99.9% (IQR 93.3%–100.0%) | median 99.1%% (IQR 87.0%–100.0%) |
- Recurrence of any atrial tachyarrhythmia ≥30 s — Difference across the three groups
- P = .65
- Reduction in AF burden vs pre-ablation monitoring — Difference across the three groups
- P = .38
Original publication
Atrial fibrillation progression after cryoablation vs. radiofrequency ablation: the CIRCA-DOSE trial. Eur Heart J. Published 25 August 2023. doi:10.1093/eurheartj/ehad572
Summarised from the published abstract; every number is checked against it