Valvular & structural heart diseaseCohort study
Atrial Functional Tricuspid Regurgitation in Patients Undergoing Transcatheter Aortic Valve Replacement
- Retrospective cohort study
Authors' conclusion
In TAVR patients, afTR is an independent predictor for TR persistence. Moreover, TR persistence is associated with increased 3-year all-cause mortality.
Study context
- Population
- Patients undergoing transcatheter aortic valve replacement (TAVR) for severe AS (January 2013 to December 2020) with concomitant at least moderate tricuspid regurgitation (TR) at baselineof 3,474 TAVR patients
- Participants
- 363 patients
- Exposure
- Atrial functional tricuspid regurgitation (afTR) vs non-afTR
- afTRn = 178
- non-afTRn = 185reference
- Outcome
- TR development after TAVR
Main finding
TR improvement after TAVR
Adjusted odds ratio
2.80
95% CI 1.66–4.76
P < 0.001
By group
afTR vs non-afTR
adjusted OR 2.80 (95% CI 1.66–4.76); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Aggravation of TR after TAVR
P = 0.013
All-cause mortality, TR persistence vs TR improvement · 3 years
- Significantly higher with TR persistence than with TR improvement
- P < 0.001
Original publication
Atrial Functional Tricuspid Regurgitation in Patients Undergoing Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 8 January 2024. doi:10.1016/j.jcin.2023.10.069
Summarised from the published abstract; every number is checked against it