Valvular & structural heart diseaseResearch article
Atrial Secondary Mitral Regurgitation Outcomes Following Mitral Transcatheter Edge-to-Edge Repair: Results From the EXPANDed Studies
- analysis of the EXPANDed studies (EXPAND and EXPAND G4)
- echocardiographic core laboratory assessment
Authors' conclusion
In the largest population of patients with aSMR assessed by an echocardiographic core laboratory, MTEER safely and significantly reduced MR with improvements in quality of life and reduction in heart failure hospitalization through 1 year.
Study context
- Population
- Patients with atrial secondary mitral regurgitation (aSMR) treated with mitral transcatheter edge-to-edge repair (MTEER)met criteria for aSMR, of the 967 patients with SMR treated with MTEER
- Participants
- 160 patients
Main finding
As reported in the abstract
Acute procedural success
Acute procedural success
97.5%
Further findings
MR reduction to ≤1+ · 1 year
- MR ≤1+
- 95.2%
Quality of life (Kansas City Cardiomyopathy Questionnaire Overall Summary) · 1 year
- Improvement
- +19 pt
- significant
Functional capacity · 1 year
- New York Heart Association I/II
- 80%
All-cause mortality · 1 year
- All-cause mortality rate
- 9%
Heart failure hospitalization rates, pre- to post-MTEER · 1 year
- Reduction
- 56%
Baseline characteristics
- Age
- 78±8 years
- Kansas City Cardiomyopathy Questionnaire Overall Summary score
- 48±27 pts
- Small left ventricular and large left atrial (LA) dimensions
Original publication
Atrial Secondary Mitral Regurgitation Outcomes Following Mitral Transcatheter Edge-to-Edge Repair: Results From the EXPANDed Studies. Circ Cardiovasc Interv. Published 21 January 2026. doi:10.1161/circinterventions.125.015883
Summarised from the published abstract; every number is checked against it