Arrhythmias & electrophysiologyCohort study
Atrioventricular synchrony maintained by a dual-chamber leadless pacemaker in real-world conditions
- Prospective single-arm clinical study
- multicentre
- independent Holter core laboratory
Authors' conclusion
A dual-chamber leadless pacing system demonstrated >96% overall AV synchrony for a 24 h period of daily living while programmed to clinically appropriate settings, thus showing that true dual-chamber DDD(R) pacing can be maintained in a real-world environment.
Study context
- Population
- Patients with standard indications for dual-chamber pacing, 24 h Holter after the 3-month visit during daily living
- Participants
- 47 analysable patients
- Outcome
- AV synchrony (proportion of synchronous beats, PR intervals within paced and sensed AV delay bounds)
- Follow-up
- 24 h period of daily living after the 3-month visit
Main finding
As reported in the abstract
Mean atrioventricular (AV) synchrony (% of beats)
96.7%
Mean A-to-V transmission success rate
93.4%
Mean V-to-A transmission success rate
92.1%
Observational data: associations, not effects.
Further findings
AV synchrony by implant indication (sinus node vs AV block)
- No significant differences in AV synchrony between sinus node and AV block patients
AV synchrony across AV paced/sensed cycle combinations and heart rate ranges (including >100 b.p.m.)
- AV synchrony sustained across all combinations and heart rate ranges
- >90%
Original publication
Summarised from the published abstract; every number is checked against it