Arrhythmias & electrophysiologySecondary analysis
Autonomic effects and ablation success after pulsed field and cryoballoon ablation: a SINGLE SHOT CHAMPION substudy
- Secondary analysis of the SINGLE SHOT CHAMPION randomised trial
- multicentre
Authors' conclusion
Despite reduced cardiac ANS modulation, PFA was associated with a superior arrhythmia-free outcome compared to CBA.
Study context
- Population
- Patients with symptomatic paroxysmal atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI), with implantable cardiac monitor
- Participants
- 210 patients
- Comparison
- Pulsed field ablation (PFA) vs cryoballoon ablation (CBA) for PVI
- PFAn = 105
- CBAn = 105reference
Primary result
As reported in the abstract
HRV · Days 1-2
P < 0.001
Further findings
Freedom from arrhythmia recurrence · 12 months
P = 0.046
| Outcome | P value |
|---|---|
| HRV by arrhythmia recurrence (CBA) | P = 0.002 |
- Heart rate variability (HRV) by arrhythmia recurrence (CBA): CBA without recurrence 67 ms
- HRV by arrhythmia recurrence (CBA): CBA with recurrence 84 ms
HRV by arrhythmia recurrence (CBA)
- HRV did not differ between PFA patients with and without recurrence
Original publication
Autonomic effects and ablation success after pulsed field and cryoballoon ablation: a SINGLE SHOT CHAMPION substudy. Europace. Published 18 June 2026. doi:10.1093/europace/euag152
Summarised from the published abstract; every number is checked against it