Cardio-oncology & other

Autopsy Findings in Cases of Fatal COVID-19 Vaccine-Induced Myocarditis

ESC Heart FailPublished Systematic review of autopsy reports

Authors' conclusion

The temporal relationship, internal and external consistency seen among cases in this review with known COVID-19 vaccine-induced myocarditis, its pathobiological mechanisms, and related excess death, complemented with autopsy confirmation, independent adjudication, and application of the Bradford Hill criteria to the overall epidemiology of vaccine myocarditis, suggests that there is a high likelihood of a causal link between COVID-19 vaccines and death from myocarditis.

Study context

Population
Published autopsy cases of COVID-19 vaccine-induced myocarditis as possible cause of death, through 3 July 202314 papers
Participants
28 cases
Outcome
Causal link between COVID-19 vaccination and death from myocarditis (independent adjudication)
Methodological detailsindependent adjudication by three physicians
  • Independent adjudication by three physicians

Pooled result

As reported in the abstract

Deaths most likely causally linked to COVID-19 vaccination

Deaths adjudicated as most likely causally linked to COVID-19 vaccination

28 of 28

Further pooled results

Case characteristics

Cardiovascular system the only organ system affected
26 cases
Myocarditis as consequence of multisystem inflammatory syndrome
2 cases
Mean age at death
44.4 years
Mean days from last vaccination to death
6.2
Median days from last vaccination to death
3

Original publication

Autopsy Findings in Cases of Fatal COVID-19 Vaccine-Induced Myocarditis. ESC Heart Fail. Published 14 January 2024. doi:10.1002/ehf2.14680

Summarised from the published abstract; every number is checked against it

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