Cohort study
B-type natriuretic peptide levels predict long-term mortality in a large cohort of adults with congenital heart disease
- Retrospective cohort study
- single-centre
- tertiary ACHD centre
Authors' conclusion
Baseline BNP and temporal BNP changes are both significantly associated with all-cause mortality in ACHD independent of congenital heart disease diagnosis, complexity, anatomic/haemodynamic features, and/or systolic systemic ventricular function.
Study context
- Population
- Consecutive adults with congenital heart disease under long-term follow-up at a tertiary ACHD centre, 2006–201911,974 BNP measurements
- Participants
- 3,392 adults
- Exposure
- BNP levels and all-cause mortality
- Outcome
- All-cause mortality
- Follow-up
- Median 8.6 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Baseline BNPunivariable
1.16(1.15–1.18)
P < 0.001Baseline BNPmultivariable
1.13(1.08–1.18)
P < 0.001Temporal changes in BNP levelsunivariable
1.22(1.19–1.26)
P < 0.001Temporal changes in BNP levelsmultivariable
1.19(1.12–1.26)
P < 0.001Highest quartile of baseline BNP (>107 ng/L)risk of death
5.8(4.91–6.79)
P < 0.001Highest quartile of temporal BNP change (>35 ng/L)risk of death
3.6(2.93–4.40)
P < 0.001- Patients who died
- 615 (18.1%)
Observational data: associations, not effects.
Original publication
B-type natriuretic peptide levels predict long-term mortality in a large cohort of adults with congenital heart disease. Eur Heart J. Published 14 May 2024. doi:10.1093/eurheartj/ehae254
Summarised from the published abstract; every number is checked against it