Coronary disease & ACSRandomised controlled trial
Balloon Lithotripsy Added to Conventional Preparation Before Stent Implantation in Severely Calcified Coronary Lesions
- Randomised controlled trial
- international
- assessor-blinded
Authors' conclusion
Adding lithotripsy to lesion preparation using conventional techniques before stent implantation in severely calcified lesions reduced the combined incidence of procedural failure or target vessel failure at 1 year. The reduced incidence was driven primarily by a reduction in residual area stenosis ≥20%.
Study context
- Population
- Patients with severely calcified coronary lesions undergoing stent implantation
- Participants
- 99 vs 101
- Comparison
- Lithotripsy vs Conventional
- Lithotripsyn = 99
- Conventionaln = 101reference
- Primary endpoint
- Procedural failure (failed or no stent delivery, or residual area stenosis ≥20% by optical coherence tomography) or target vessel failure (cardiac death, MI, or clinically driven revascularization)
- Follow-up
- 1 year
Primary result
As reported in the abstract
Relative risk
0.69
95% CI 0.48–0.97
P = 0.02
Events by treatment group
Lithotripsy vs Conventional
RR 0.69 (95% CI 0.48–0.97); P = 0.02
Further findings
| Outcome | Lithotripsy | Conventional | RR (95% CI) | |
|---|---|---|---|---|
| Residual area stenosis ≥20% (most frequent component of primary endpoint) | 32% | 45% | 0.73 (0.49–1.04) | |
| 0.512Relative risk (log scale) |
Safety
Safety endpoints
- Safety endpoints did not differ between groups
Original publication
Balloon Lithotripsy Added to Conventional Preparation Before Stent Implantation in Severely Calcified Coronary Lesions. JACC Cardiovasc Interv. Published 15 December 2025. doi:10.1016/j.jcin.2025.09.028
Summarised from the published abstract; every number is checked against it