Bariatric surgery and cardiovascular outcomes in patients with obesity, metabolic dysfunction-associated steatotic liver disease, and coronary artery disease: a population-based matched cohort study
Authors' conclusion
BS in patients with MASLD, obesity, and pre-existing CAD can considerably reduce the risk of recurring cardiovascular events and markedly improve survival immediately within the first year of BS and can persist long-term, even a decade after BS.
Study context
- Population
- Adult patients (>18 years) with MASLD, obesity (body mass index ≥35 kg/m²) and pre-existing coronary artery disease (CAD), 1 January 2005 to 31 December 2022patients in each group after propensity score matching (PSM)
- Participants
- 1,038 patients
- Exposure
- Patients with a bariatric surgery (BS) were compared with those with no history of BS.
- BSn = 1,038
- No history of BSn = 1,038reference
- Outcome
- Incidence of MACE, heart failure, cerebrovascular events, and coronary artery procedures or surgeries
- Follow-up
- Years 1, 3, 5, 7, and 10
Methodological details1:1 propensity score matching (PSM), TriNetX data
- 1:1 propensity score matching (PSM)
- TriNetX data
Main finding
As reported in the abstract
BS vs no history of BSHazard ratio (95% CI)
MACE at year 1
0.56(0.39–0.80)
Cerebrovascular disease at year 1
0.62(0.46–0.82)
Coronary artery procedures and surgeries at year 1
0.65(0.42–0.98)
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality (secondary outcome) · years 3, 5, 7, and 10
- BS patients had significantly lower 3-, 5-, 7-, and 10-year all-cause mortality
Sensitivity analysis
- Sensitivity analysis confirmed these findings
Original publication
Bariatric surgery and cardiovascular outcomes in patients with obesity, metabolic dysfunction-associated steatotic liver disease, and coronary artery disease: a population-based matched cohort study. Eur Heart J Qual Care Clin Outcomes. Published 20 January 2025. doi:10.
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