Coronary disease & ACSMeta-analysis
Baseline anaemia and short dual antiplatelet therapy in high bleeding risk patients undergoing percutaneous coronary intervention
- Pooled analysis of three prospective trials (XIENCE Short dual antiplatelet therapy (DAPT) Program)
- propensity score stratification
- subgroup analysis by baseline anaemia
Authors' conclusion
Among HBR patients undergoing PCI, abbreviated DAPT was associated with comparable ischemic outcomes regardless of anemia status. In patients with baseline anemia, 1-month DAPT was associated with lower major bleeding without an apparent ischemic trade-off.
Study context
- Population
- High bleeding risk (HBR) patients undergoing percutaneous coronary intervention (PCI) with cobalt-chromium everolimus-eluting stents; anaemia = Hb <11 g/dL514 (15.3%) anaemic
- Participants
- 3,364 patients
- Comparison
- 1-month vs 3-month DAPT by baseline anaemia
- Outcome
- All-cause death or MI
- Follow-up
- 1 year
Pooled result
As reported in the abstract
All-cause death or MI, anaemic patients (subgroup)
Adjusted hazard ratio
0.94
95% CI 0.59–1.52
P = 0.807
By group
1-month DAPT vs 3-month DAPT
adjusted HR 0.94 (95% CI 0.59–1.52); P = 0.807
Further pooled results
Ischaemic and bleeding events, anaemic vs non-anaemic · 1 year
- Anaemic patients had higher rates of both ischaemic and bleeding events than non-anaemic patients
Safety
| Outcome | 1-month DAPT | 3-month DAPT | adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Major bleeding, anaemic patients (subgroup) · 1 year | 6.1% | 11.1% | 0.49 (0.24–1.00) | P = 0.050 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Major bleeding, anaemic patients (subgroup) · 1 year
- Non-anaemic patients: bleeding outcomes similar irrespective of DAPT duration
Original publication
Baseline anaemia and short dual antiplatelet therapy in high bleeding risk patients undergoing percutaneous coronary intervention. Eur J Prev Cardiol. Published 23 July 2026. doi:10.1093/eurjpc/zwag384
Summarised from the published abstract; every number is checked against it