Cardio-oncology & otherCohort study
Baseline Cardiac Parameters as Biomarkers of Radiation Cardiotoxicity in Lung Cancer
- Retrospective cohort study
- single-centre
Authors' conclusion
The present findings suggest that cardiac history and RT planning scan parameters may offer potential utility in prospectively evaluating cardiotoxicity risk following RT for patients with lung cancer.
Study context
- Population
- Patients who underwent definitive radiation therapy (RT) for non-small cell lung cancer with modern planning techniques, 2015–2020
- Participants
- 478 patients
- Outcome
- MACE and mortality after RT (predictive value of clinical and imaging-based cardiac parameters)
Main finding
As reported in the abstract
MACE
Patients developing major adverse cardiac events (MACE) (88 events)
77 (16%)
Median time to event
16.3 months
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Atrial arrhythmia, by left atrial enlargement on RT planning scans · 5 years · 14% [95% CI: 9%-20%] vs 4% [95% CI: 2%-8%] | P = 0.001 |
| HF, by LV enlargement on RT planning scans · 5 years · 13% [95% CI: 8%-18%] vs 6% [95% CI: 3%-10%] | P = 0.007 |
| MI, by coronary calcium · 4.2% [95% CI: 2%-7%] vs 0% [95% CI: 0%-0%]; not associated | P = 0.094 |
Survival
- No cardiac imaging metrics both clinically and statistically associated with survival
Original publication
Baseline Cardiac Parameters as Biomarkers of Radiation Cardiotoxicity in Lung Cancer. JACC CardioOncol. Published 2 July 2024. doi:10.1016/j.jaccao.2024.05.009
Summarised from the published abstract; every number is checked against it