Heart failure & cardiomyopathiesCohort study
“Baseline Characteristics and Utilization of Medical Therapies in Acute Hospitalized and Chronic Heart Failure Patients Enrolled in Global Registries and Surveys Programme-Heart Failure (GRASP-HF): Differences Between ICARe-HF and Non-ICARe-HF Centres”
- prospective, multicentre, international observational study
Authors' conclusion
Participation in the ICARe-HF programme was associated with more comprehensive implementation of contemporary GDMT, particularly in HFrEF. The association with in-hospital mortality was attenuated after adjustment and should be considered exploratory.
Study context
- Population
- Acute hospitalized and chronic heart failure patients enrolled in GRASP-HF, stratified by ICARe-HF centre participation63.3% chronic HF (CHF), 36.7% AHF, 51.3% from ICARe-HF participating centres
- Participants
- 10,936 participants
- Exposure
- patients managed in centres participating or not participating in the ICARe-HF programme
Main finding
As reported in the abstract
Baseline characteristics
- Patients from ICARe-HF participating centres were older, more comorbid but with less severe congestion
Observational data: associations, not effects.
Further findings
| Outcome | ICARe-HF centres | Non-ICARe-HF centres | OR (95% CI) | |
|---|---|---|---|---|
| Quadruple therapy implementation in HFrEF · after adjustment | 1.73 (1.17–2.55) | |||
| CHF | 47% | 40% | ||
| AHF discharge | 27% | 24% | ||
| In-hospital mortality · after multivariable adjustment; association attenuated · should be considered exploratory | crude 2.3% | crude 5.5% | 0.87 (0.48–1.56) | |
| 0.20.5125Odds ratio (log scale) |
Guideline-directed-medical-therapy (GDMT) utilization in CHF and AHF
- ICARe-HF centres demonstrated greater GDMT utilization, particularly angiotensin receptor-neprilysin inhibitors and sodium-glucose-cotransporter-2 inhibitors
Target doses
- Target doses remained suboptimal, particularly after AHF
Original publication
“Baseline Characteristics and Utilization of Medical Therapies in Acute Hospitalized and Chronic Heart Failure Patients Enrolled in GRASP-HF: Differences Between ICARe-HF and Non-ICARe-HF Centres”. Eur J Heart Fail. Published 13 October 2026. doi:10.1093/ejhf/xuag317
Summarised from the published abstract; every number is checked against it