Heart failure & cardiomyopathiesCohort study
Baseline characteristics in the TransitionCHF study: asymptomatic patients with heart failure and reduced ejection fraction
- prospective observational TransitionCHF study
Authors' conclusion
Patients included in the TransitionCHF study are younger and suffer from fewer comorbidities as compared with symptomatic heart failure patients. Associations between NT-proBNP levels and markers of exercise performance were weak.
Study context
- Population
- Patients with asymptomatic systolic left ventricular dysfunction (ASLVD), New York Heart Association (NYHA) I, ejection fraction ≤ 40%individuals with ASLVD NYHA I recruited
- Participants
- 1,005 patients
- Exposure
- Patient characteristics compared with other studies involving patients with symptomatic heart failure
Main finding
As reported in the abstract
Baseline characteristics
Mean age
60 ± 14 years
Women
18%
Mean ejection fraction
36%
Mean left ventricular end-diastolic diameter
59 mm
Observational data: associations, not effects.
Further findings
Comparison with studies of symptomatic heart failure
- Age younger
- ≈ 5 years
- Frequency of comorbidities lower
Correlations of SF-36 physical functioning score
- MQ (moderate)
- r = −0.44
- 6-min walking distance (weak)
- r = 0.32
- peak VO2 at ergospirometry (weak)
- r = 0.28
- HAF17 (weak)
- r = −0.34
Correlations of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels
- peak VO2 (weak)
- r = −0.29
- 6-min walk distance (weak)
- r = −0.21
Original publication
Baseline characteristics in the TransitionCHF study: asymptomatic patients with heart failure and reduced ejection fraction. ESC Heart Fail. Published 21 January 2026. doi:10.1093/eschf/xvag012
Summarised from the published abstract; every number is checked against it