Arrhythmias & electrophysiologyCohort study
Baseline left atrial low-voltage area predicts recurrence after pulmonary vein isolation: WAVE-MAP atrial fibrillation (AF) results
- Prospective cohort study
- multicentre
- 18 centres
Authors' conclusion
Larger extension of LVA was associated with an increased risk of arrhythmia recurrence.
Study context
- Population
- Patients with AF undergoing de novo pulmonary vein isolation (PVI)-only radiofrequency catheter ablation
- Participants
- 300 patients · 18 centres
- Exposure
- Left atrial low-voltage area (LVA) extent vs AF/AF/atrial flutter (AFL)/atrial tachycardia (AT) recurrence after PVI-only ablation
- Paroxysmal AF (PAF)n = 113
- Early persistent AF (PsAF)n = 86
- Non-early PsAFn = 101
- Outcome
- AF/AFL/AT recurrence after a single PVI procedure, by pre-ablation mapping characteristics
- Follow-up
- 12 months
Main finding
As reported in the abstract
AF/AFL/AT recurrence by LVA extent (Cox model)
Hazard ratio (95% CI)P value
Low-voltage area (<0.5 mV) >28% of the left atrium in SR
4.82(2.08–11.18)
P = 0.0003>72% in AFLVA (<0.5 mV) >72% of the left atrium in AF
5.66(2.34–13.69)
P = 0.0001- Freedom from AF/AFL/AT recurrence at 12 months
- 75.5%
Observational data: associations, not effects.
Original publication
Baseline left atrial low-voltage area predicts recurrence after pulmonary vein isolation: WAVE-MAP AF results. Europace. Published 20 July 2023. doi:10.1093/europace/euad194
Summarised from the published abstract; every number is checked against it