Acute cardiac care & resuscitationSecondary analysis
Baseline measurements of cellular respiration affect the response to thiamine treatment in post-arrest patients
- post hoc analysis of two randomized trials
Authors' conclusion
Thiamine supplementation was associated with reduced lactate in patients with preserved mitochondrial functional reserve. Baseline mitochondrial respiration may serve as a biomarker to identify critically ill patients most likely to benefit from metabolic resuscitation therapies.
Study context
- Population
- Cardiac arrest patients with baseline mitochondrial oxygen consumption rate measurements in peripheral blood mononuclear cellspatients with baseline OCR measurements included in the analysis
- Participants
- Seventy-four patients
- Comparison
- thiamine compared to placebo
- thiaminen = 40
- placebon = 34
- Primary endpoint
- change in lactate
- Follow-up
- 24 h
Primary result
As reported in the abstract
GMR
0.83
95% CI 0.64–1.09
P = 0.19
Further findings
| Outcome | GMR (95% CI) | P value |
|---|---|---|
| Lactate among patients with maximal respiration above the median (subgroup) · 24 h | 0.61 (0.44–0.83) | P = 0.003 |
| Lactate among patients with spare respiration above the median (subgroup) · 24 h | 0.53 (0.38–0.75) | P < 0.001 |
Original publication
Baseline measurements of cellular respiration affect the response to thiamine treatment in post-arrest patients. Resuscitation. Published 25 February 2026. doi:10.1016/j.resuscitation.2026.111029
Summarised from the published abstract; every number is checked against it