Heart failure & cardiomyopathiesSecondary analysis
Bendopnea prevalence and prognostic value in older patients with heart failure: FRAGILE-HF–SONIC-HF post hoc analysis
- Post hoc analysis of the FRAGILE-HF and SONIC-HF prospective observational cohort studies
- multicentre
- main and validation cohorts
Authors' conclusion
Bendopnea was observed in a relatively small proportion of older patients hospitalized for heart failure before discharge. However, its presence was significantly associated with an increased risk of all-cause mortality.
Study context
- Population
- Older patients hospitalised for HFFRAGILE-HF 1243
- Comparison
- Bendopnea vs no bendopnea
- Primary endpoint
- All-cause mortality after discharge
- Follow-up
- 2 years
Primary result
As reported in the abstract
2-year all-cause mortality
Bendopnea vs No bendopneaHazard ratio (95% CI)P value
FRAGILE-HF (main cohort), adjusted for conventional risk factors
2.11(1.18–3.78)
P = 0.012SONIC-HF (validation cohort), adjusted for conventional risk factors
4.20(1.63–10.79)
P = 0.003- Higher mortality with bendopnea, FRAGILE-HF (Kaplan-Meier)
- log-rank P = 0.006
- Higher mortality with bendopnea, SONIC-HF (Kaplan-Meier)
- log-rank P = 0.014
Further findings
Prevalence of bendopnea · before discharge
- FRAGILE-HF
- 31 (2.5%)
- SONIC-HF
- 10 (4.4%)
All-cause death over 2-year follow-up (whole cohort)
- FRAGILE-HF
- 20.8%
- SONIC-HF
- 21.9%
Original publication
Bendopnea prevalence and prognostic value in older patients with heart failure: FRAGILE-HF–SONIC-HF post hoc analysis. Eur J Prev Cardiol. Published 4 April 2024. doi:10.1093/eurjpc/zwae128
Summarised from the published abstract; every number is checked against it