Acute cardiac care & resuscitation
Beneficial Effects of Ketone Ester in Patients With Cardiogenic Shock: A Randomized, Controlled, Double-Blind Trial
Authors' conclusion
Treatment with KE improved cardiac output, biventricular function, tissue oxygenation, and glycemic control in patients with CS
Study context
- Population
- Patients with cardiogenic shockcrossover
- Participants
- 12 patients
- Comparison
- Ketone ester vs placebo
- Primary endpoint
- Hemodynamic effects (cardiac output)
- Follow-up
- 3 hours after each intervention
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Cardiac output (AUC of relative change)
P = 0.044
Further findings
Circulating 3-hydroxybutyrate
P < 0.001
| Outcome | Increase (W) (95% CI) | P value | |
|---|---|---|---|
| Cardiac power output, mixed venous saturation, forearm perfusionCardiac power output | 0.07 (0.01–0.14) | P = 0.037 | |
| −0.100.10.2Difference, W (linear scale) |
| Outcome | Increase (percentage points) (95% CI) | P value | |
|---|---|---|---|
| Cardiac power output, mixed venous saturation, forearm perfusionMixed venous saturation | 3 (1–5) | P = 0.010 | |
| Cardiac power output, mixed venous saturation, forearm perfusionForearm perfusion | 3 (0–6) | P = 0.026 | |
| −50510Difference, percentage points (linear scale) |
Ventricular filling pressures, HR, mean arterial and pulmonary arterial pressures
- Right ventricular filling pressure reduced
- P = 0.048
- Left ventricular filling pressure reduced
- P = 0.017
- HR and mean arterial and pulmonary arterial pressures remained similar
LVEF, glucose, insulin
- LVEF improved
- 4 percentage points (95% CI: 2-6 percentage points; P = 0.005)
- Glucose decreased
- 2.6 mmol/L (95% CI: −5.2 to 0.0; P = 0.047)
- Insulin levels remained unaltered
Original publication
Beneficial Effects of Ketone Ester in Patients With Cardiogenic Shock: A Randomized, Controlled, Double-Blind Trial. JACC Heart Fail. Published 12 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →