Randomised controlled trial
Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction
- Randomised controlled trial
- open-label
- parallel-group
- 45 centres in Sweden, Estonia and New Zealand
Authors' conclusion
Among patients with acute myocardial infarction who underwent early coronary angiography and had a preserved left ventricular ejection fraction (≥50%), long-term beta-blocker treatment did not lead to a lower risk of the composite primary end point of death from any cause or new myocardial infarction than no beta-blocker use.
Study context
- Population
- Patients with acute MI who underwent coronary angiography and had LVEF ≥50%95.4% from Sweden
- Participants
- 5,020 patients
- Comparison
- Long-term beta-blocker vs no beta-blocker after MI
- Beta-blockern = 2,508
- No beta-blockern = 2,512reference
- Primary endpoint
- Death from any cause or new MI
- Follow-up
- Median 3.5 years
Primary result
As reported in the abstract
Hazard ratio
0.96
95% CI 0.79–1.16
P = 0.64
Events by treatment group
Secondary outcomes
Secondary end points (cumulative incidence)
All-cause death
CV death
MI
Hospitalisation for AF
Hospitalisation for HF
Secondary end points (cumulative incidence)
- Beta-blocker did not appear to lower cumulative incidence of secondary end points
Safety
Safety end points
Hospitalisation for bradycardia, 2nd/3rd-degree AV block, hypotension, syncope or pacemaker implantation
Hospitalisation for asthma or COPD
Hospitalisation for stroke
Original publication
Summarised from the published abstract; every number is checked against it