Beyond early LDL cholesterol lowering to prevent coronary atherosclerosis in familial hypercholesterolaemia
Main finding · Coronary plaque prevalenceResult — go to the resultOdds ratio 3.66 95% CI 1.62–8.27Authors' conclusion
Lifetime exposure to LDL-C determines coronary plaque burden in FH
Study context
- Population
- Young patients with familial hypercholesterolaemia (FH) and unaffected controlsmean age 41 ± 3 years
- Exposure
- FH patients vs unaffected controls
- FHn = 90
- Controlsn = 45reference
- Outcome
- Extent of subclinical coronary atherosclerosis and its association with lifetime cumulative LDL-C exposure
Methodological detailsage- and sex-matched controls, coronary CT angiography (CCTA) with artificial intelligence-guided analysis
- Age- and sex-matched controls
- CCTA with artificial intelligence-guided analysis
Main finding
Coronary plaque prevalence
Odds ratio
3.66
95% CI 1.62–8.27
Events by group
FHvs Controls
OR 3.66 (95% CI 1.62–8.27)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Plaque prevalence, FH above-vs below-median cumulative LDL-C exposure | 3.62 (1.62–8.27) | P = 0.001 | |
| 0.10.31310Odds ratio (log scale) |
mmol/L ∗ years
| Outcome | FH | Early treated | Late treated | Controls | P value |
|---|---|---|---|---|---|
| Cumulative LDL-C exposure | 181 (SD 54) | — not stated in the abstract | — not stated in the abstract | 105 (SD 33) | |
| Cumulative LDL-C exposure, early vs late treated FH | — not stated in the abstract | 167 (SD 41) | 194 (SD 61) | — not stated in the abstract | P = 0.045 |
— not stated in the abstract
Cumulative low density lipoprotein cholesterol (LDL-C) exposure, early vs late treated FH
- No significant difference in coronary atherosclerosis between early and late treated
Original publication
Beyond early LDL cholesterol lowering to prevent coronary atherosclerosis in familial hypercholesterolaemia. Eur J Prev Cardiol. Published 19 January 2024. doi:10.
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