Arrhythmias & electrophysiologyResearch article
Bifascicular pacing: A novel multipoint left conduction system pacing method for cardiac resynchronization
- study
Authors' conclusion
BiF pacing is a novel physiological pacing method that more completely recruits the left conduction system. Compared with single-fascicle pacing, it improves electrical and mechanical synchrony, potentially translating to superior clinical outcomes.
Study context
- Population
- Cardiac resynchronization therapy (CRT) candidates who received bifascicular (BiF) pacingCRT candidates who received BiF pacing
- Participants
- 28 candidates
- Comparison
- synchrony between BiF and single-fascicle pacing
Main finding
As reported in the abstract
Electrical and mechanical synchrony (QRS duration, QRS area, global RWPT, global dV/dt time, global longitudinal strain, global work efficiency, PSD)
- Compared with single-fascicle pacing, BiF pacing resulted in significantly shorter QRS duration, lower QRS area, shorter global R-wave peak time (RWPT), shorter global dV/dt time, higher global longitudinal strain and global work efficiency, and lower peak strain dispersion (PSD)
- No differences between left inferior fascicle (LIF) and left superior fascicle (LSF) pacing with respect to these parameters
Further findings
Correlation of lead I dV/dt time and lead I RWPT with PSD
- Lead I dV/dt time vs PSD
- r = 0.79
- Lead I RWPT vs PSD
- r = 0.67
Baseline characteristics
- age
- 74.6 ± 12.2 years
- female
- 36%
- left ventricular ejection fraction
- 37.2% ± 10.6%
Original publication
Bifascicular pacing: A novel multipoint left conduction system pacing method for cardiac resynchronization. Heart Rhythm. Published 13 October 2025. doi:10.1016/j.hrthm.2025.10.020
Summarised from the published abstract; every number is checked against it