Arrhythmias & electrophysiology
Bilateral Cardiac Sympathetic Denervation for Refractory Multifocal Premature Ventricular Contractions in Patients With Nonischemic Cardiomyopathy
Authors' conclusion
BCSD is effective for the management of refractory PVCs and ventricular tachycardia who have failed previous ablation therapy.
Study context
- Population
- Patients with >5% premature ventricular contraction (PVC) burden and nonischemic cardiomyopathy (NICM) who failed medical and ablation therapies
- Participants
- 43 patients
- Exposure
- Post-BCSD vs pre-BCSD
- Outcome
- PVC burden resolution, improvement in left ventricular ejection fraction (LVEF), and cessation of AADs
- Follow-up
- 1-year follow-up
Methodological detailssingle-group, pre-post comparison
- Single-group
- Pre-post comparison
Main finding
As reported in the abstract
AAD use
P < 0.001
| Outcome | Pre-BCSD | Post-BCSD | P value |
|---|---|---|---|
| PVC burden | 23.7% ± 9.9% | 1.3% ± 1.1% | P < 0.001 |
| LVEF | 38.7% ± 7.8% | 46.3% ± 9.5% | P < 0.001 |
Observational data: associations, not effects.
Further findings
ICD therapies
P < 0.001
| Outcome | Pre-BCSD | Post-BCSD | P value |
|---|---|---|---|
| NYHA functional classMean | 2.5 (SD 0.5) | 1.4 (SD 0.2) | P < 0.001 |
| No mortality or major complications · 1-year follow-upRemaining patients still within first year postprocedure | — not stated in the abstract | 81.4% |
— not stated in the abstract
No mortality or major complications · 1-year follow-up
- Free of mortality or major complications
- 81.4% (n = 35)
- Remaining patients still within first year postprocedure
Safety
Major intraoperative complications (hemothorax and chylothorax)
- Major intraoperative complications
- 4.7%
Original publication
Bilateral Cardiac Sympathetic Denervation for Refractory Multifocal Premature Ventricular Contractions in Patients With Nonischemic Cardiomyopathy. JACC Clin Electrophysiol. Published 8 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →