Arrhythmias & electrophysiology
Bilateral cardiac sympathetic denervation in patients with congenital long QT syndrome
Authors' conclusion
Less than 5% of all patients receiving denervation therapy underwent BiCSD. When BiCSD was chosen, it was almost always done in a staged sequential manner beginning with LCSD first and when driven by the arrhythmogenicity of the LQTS substrate, despite otherwise optimized guideline-directed therapies.
Study context
- Population
- Patients with congenital Long QT syndrome (LQTS) who underwent sympathetic denervation at a tertiary referral centreof 1638 LQTS patients
- Participants
- 234 patients
- Exposure
- Bilateral cardiac sympathetic denervation (BiCSD) vs left cardiac sympathetic denervation (LCSD) only
- BiCSDn = 11
- Outcome
- Frequency and settings of BiCSD use; CEs (appropriate ICD shock, arrhythmic syncope or sudden cardiac arrest) before LCSD, after LCSD and after BiCSD
Methodological detailssingle-centre, tertiary referral centre
- Single-centre
- Tertiary referral centre
Main finding
As reported in the abstract
Use of BiCSD
| Group | Value | Females |
|---|---|---|
| BiCSD | 4.7% | 6 [55%] |
BiCSD
Value4.7%
Females6 [55%]
- Continued cardiac events (CEs) post-LCSD was the predominant determinant to return for BiCSD
- 3.8 CEs per patient on average
Observational data: associations, not effects.
Further findings
Age at diagnosis
P = 0.06
Symptomatic
P = 0.07
CEs post-BiCSD · over 60 combined years of follow-up
- Patients without CE post-BiCSD
- 4
- Other patients, average nonlethal CEs
- 3.6
- Other patients (n)
- 7
Original publication
Bilateral cardiac sympathetic denervation in patients with congenital long QT syndrome. Heart Rhythm. Published 17 March 2023. doi:10.
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