Heart failure & cardiomyopathiesCohort study
Bioimpedance-derived compartmental fluid status and prognosis in chronic heart failure
- Prospective cohort study
Authors' conclusion
Compartment-specific estimates of fluid overload obtained with the BioScan Touch i8 IVF were independently associated with adverse outcomes in ambulatory patients with chronic HF, beyond NT-proBNP and clinical surrogates of congestion. These findings support the potential role of BIA-derived indexes, particularly tissue fluid excess, as complementary tools for risk stratification in this population.
Study context
- Population
- Ambulatory patients with stage C chronic HF
- Participants
- 386 patients
- Exposure
- patients in the highest quartile had significantly higher risk of the composite outcome compared with Q1
Main finding
As reported in the abstract
Total fluid excess, median (Q1-Q3: 0.5, 2.3)
1.3 L
Intravascular fluid excess, median (Q1-Q3: −0.1, 0.4)
0.1 L
Tissue fluid excess, median (Q1-Q3: 1.1, 2.8)
1.9 L
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Composite of all-cause death or worsening HF — Highest quartile vs Q1 · total fluid excess · adjusted analyses | 2.11 (1.21–4.05) | P = 0.010 | |
| Composite of all-cause death or worsening HF — Highest quartile vs Q1 · intravascular fluid excess · adjusted analyses | 2.16 (1.19–3.90) | P = 0.011 | |
| Composite of all-cause death or worsening HF — Highest quartile vs Q1 · tissue fluid excess · adjusted analyses | 2.81 (1.49–5.32) | P = 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Correlation with the clinical congestion score (CCS)
- Total fluid excess rho (P < .001)
- 0.31
- Tissue fluid excess rho (P < .001)
- 0.33
Original publication
Summarised from the published abstract; every number is checked against it