Coronary disease & ACSResearch article
Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association
- Mendelian randomisation study
- inverse-variance weighted Mendelian randomization (MR)
- Benjamini-Hochberg correction
Authors' conclusion
The results of this study support a causal role of low birth weight in cardiovascular disease, even after accounting for the influence of the intrauterine environment.
Study context
- Population
- GWAS summary statistics for birth weight
- Comparison
- Genetically-predicted birth weight (overall and direct foetal effects only) and CVD risk and cardiac structure/function
- Outcome
- AF, CAD, HF, ischaemic stroke and 16 measures of cardiac structure and function
Main finding
As reported in the abstract
Lower genetically-predicted birth weight (direct foetal effects only)
Odds ratio
1.21
95% CI 1.06–1.37
P = 0.031
Lower genetically-predicted birth weight
OR 1.21 (95% CI 1.06–1.37); P = 0.031
Original publication
Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association. Eur Heart J. Published 20 September 2023. doi:10.1093/eurheartj/ehad631
Summarised from the published abstract; every number is checked against it