Heart failure & cardiomyopathiesCohort study
Biventricular Cardiac Power Reserve in Heart Failure with Preserved Ejection Fraction
- Cohort study
Authors' conclusion
Inability to enhance BCPO during exercise is associated with more advanced HFpEF, increased systemic and pulmonary vascular resistance, reduced exercise capacity and increased adverse events in patients with HFpEF.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) undergoing comprehensive echocardiography and invasive cardiopulmonary exercise testing
- Participants
- 398 patients
- Exposure
- Low vs preserved biventricular cardiac power output reserve
- Low biventricular cardiac power output (BCPO) reserven = 199
- Preserved BCPO reserven = 199reference
Main finding
As reported in the abstract
HF hospitalization or death · 2.9 (IQR 0.9-4.5) years of follow-up
Reduced BCPO reserve associated with increased risk of HF hospitalization or death (95% CI 1.73-4.42, p < 0.0001)
HR 2.77
Observational data: associations, not effects.
Further findings
Characteristics of low BCPO reserve
- Older and leaner, more AF, higher NT-proBNP, worse renal function, more impaired left ventricular (LV) global longitudinal strain, worse LV diastolic and RV longitudinal function
- Higher filling and pulmonary artery pressures at rest; similar central pressures during exercise
- Higher exertional systemic and pulmonary vascular resistances; more impaired exercise capacity
Original publication
Biventricular Cardiac Power Reserve in Heart Failure with Preserved Ejection Fraction. Eur J Heart Fail. Published 24 April 2023. doi:10.1002/ejhf.2867
Summarised from the published abstract; every number is checked against it